60 Day Notice

30024

Federal Register / Vol. 72, No. 103 / Wednesday, May 30, 2007 / Notices

agreement may be required to receive
copies of the patent applications.
SUPPLEMENTARY INFORMATION: The patent
applications intended for licensure
disclose and/or cover the following:

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E–039–2003 ‘‘Combinatorial Therapy
for Protein Signaling Diseases’’
The invention is drawn to methods
for individualizing therapy based on
information obtained concerning
deranged signaling pathways that cause
disease. The invention includes the use
of protein microarrays to detect the
deranged signaling pathways that are
specific for the subject’s disease. The
invention covers the use of combination
therapy targeting multiple points in the
protein network. The invention is based,
in part, on the unexpected discovery
that treatment of interconnected nodes
in a protein signaling pathway can
provide a synergistic improvement in
therapeutic efficacy at reduced toxicity.
For example, a protein signaling
network of a diseased cell (e.g., colon
cancer) is analyzed and the information
obtained from the analysis is used to
select at least two drugs whose targets
are interconnected within the protein
signaling network.
E–261–1998 ‘‘Methods and Devices for
the Isolation and Analysis of Cellular
Protein Content’’
The invention is a comprehensive
Laser Capture Microdissection (LCM)
method for determining protein
characteristics of a sample tissue cell to
quantitatively discern and compare the
protein content of healthy cells versus
diseased cells. The tissue source of a
tumor metastasis is available from the
acquisition of this information. The
focus in molecular biology is moving
from genomics to proteomics, the study
of variations in the protein levels of
cells, caused by the state of the cell
itself, whether healthy or unhealthy.
The invention provides a method for
using new and innovative methods for
cell analysis. Previous methods, such as
UV-laser ablation of unwanted tissue
regions and oil well isolation of tissue
cells, were complex, labor intensive,
and did not utilize protein stabilizers.
Direct comparisons between healthy
cells and tumor cells were not made due
to limitations of the methods. The new
method consists of first using the new
LCM method to obtain pure cell
populations. Next, the sample is placed
in a device so that the proteins are
solubilized. Then the immunological
and biochemical methods and
subsequent analyses are performed.
These techniques include (but are not
limited to) immunoassays, 1D and 2D
gel electrophoresis characterization,

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Western blotting, Matrix Assisted Laser
Desorption Ionization/Time of Flight
(MALDI/TOF) and Surface Enhanced
Laser Desorption Ionization
Spectroscopy (SELDI), Protein Arrays
and Phosphoprotein Fingerprinting. The
methods listed above allow for the
direct comparison of both qualitative
and quantitative tissue content of
healthy and diseased cells, from the
same sample. The sequential method of
using LCM, protein isolation, analysis
and comparison is superior to existing
methods because the location of the
tumor can be found simply using
immunohistochemistry, and protein
characteristics, such as amino acid
sequence and binding ability can also be
discerned. In addition, by using protein
fingerprinting, the source of the tumor
metastasis is found effectively. The
invention has been tested extensively
with the different methods listed above.
This technology can be used in
hospitals and research pathology labs
for quantitative measure of protein
characteristics of cells.
The prospective exclusive license will
be royalty bearing and will comply with
the terms and conditions of 35 U.S.C.
209 and 37 CFR 404.7. The prospective
exclusive license may be granted unless,
within sixty (60) days from the date of
this published notice, NIH receives
written evidence and argument that
establishes that the grant of the license
would not be consistent with the
requirements of 35 U.S.C. 209 and 37
CFR 404.7.
Properly filed competing applications
for a license filed in response to this
notice will be treated as objections to
the contemplated license. Comments
and objections submitted in response to
this notice will not be made available
for public inspection, and, to the extent
permitted by law, will not be released
under the Freedom of Information Act,
5 U.S.C. 552.
Dated: May 21, 2007.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E7–10354 Filed 5–29–07; 8:45 am]
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DEPARTMENT OF HOMELAND
SECURITY
[Docket No. DHS–2007–0031]

Science and Technology Directorate;
Submission for Review; New
Information Collection Request for
Support of TechSolutions New
Account Request Data Form, New
Capability Gap Data Form, and
Feedback Data Form
Science and Technology
Directorate, DHS.
ACTION: 60 day notice and request for
comment.
AGENCY:

SUMMARY: The Department of Homeland
Security (DHS) TechSolutions program
is responsible for providing information,
technology, and training to the first
responder community. The
TechSolutions program will use webbased technology to collect submitter
and capability gap information. DHS is
soliciting public comment on the New
Account Request Data (DHS Form
10015), New Capability Gap Data (DHS
Form 10011), and Feedback Data (DHS
Form 10012) forms and instructions
(hereinafter ‘‘Forms Package’’) designed
to collect submitter and capability gap
information from first responders
(federal, state, local, and tribal police,
firefighters, and Emergency Medical
Service) through the TechSolutions Web
site. This notice and request for
comments is required by the Paperwork
Reduction Act of 1995 (Pub. L. 104–13,
44 U.S.C. chapter 35).
DATES: Comments are encouraged and
will be accepted until July 30, 2007.
ADDRESSES: You may submit comments,
identified by docket number DHS–
2007–0031, by one of the following
methods:
• Federal eRulemaking Portal: http://
www.regulations.gov. Follow the
instructions for submitting comments.
• E-mail: ken.rogers@dhs.gov. Include
docket number DHS–2007–0031 in the
subject line of the message.
• Mail: Science and Technology
Directorate, ATTN: OCIO/Ken Rogers,
245 Murray Drive, Bldg 410,
Washington, DC 20528.
FOR FURTHER INFORMATION CONTACT: Ken
Rogers (202) 254–6185 (this is not a toll
free number).
SUPPLEMENTARY INFORMATION: DHS
invites the general public to comment
on the new information collection
forms, as described below.
Interested parties can obtain copies of
the Forms Package by calling or writing
the point of contact listed above.
Please note that the Forms Package
include three forms for collecting

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sroberts on PROD1PC70 with NOTICES

Federal Register / Vol. 72, No. 103 / Wednesday, May 30, 2007 / Notices
submitter and capability gap
information from first responders
(federal, state, local, and tribal police,
firefighters, and Emergency Medical
Service). As explained herein, these
separate forms are intended to be
flexible and permit DHS S&T to address
reported capability gaps, leading to
improved safety and productivity
without undue bureaucratic burden.
The Department is committed to
improving its TechSolutions processes
and urges all interested parties to
suggest how these materials can further
reduce burden while seeking necessary
information under the Act.
DHS is particularly interested in
comments that:
(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility;
(2) Evaluate the accuracy of the
agency’s estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used;
(3) Suggest ways to enhance the
quality, utility, and clarity of the
information to be collected; and
(4) Suggest ways to minimize the
burden of the collection of information
on those who are to respond, including
through the use of appropriate
automated, electronic, mechanical, or
other technological collection
techniques or other forms of information
technology, e.g., permitting electronic
submissions of responses.
Overview of this Information
Collection:
(1) Type of Information Collection:
New information collection.
(2) Title of the Form/Collection:
TechSolutions New Account Request
Data Form, New Capability Gap Data
Form, and Feedback Data Form.
(3) Agency Form Number, if any, and
the applicable component of the
Department of Homeland Security
sponsoring the collection: New Account
Request Data—DHS Form 10015, New
Capability Gap Data—DHS Form 10011,
and Feedback Data—DHS Form 10012
(4) Affected public who will be asked
or required to respond, as well as a brief
abstract: Business or other for-profit,
not-for profit institutions, and state,
local or tribal government; the data
collected through the TechSolutions
Forms Package will be used to address
reported capability gaps, leading to
improved safety and productivity for
first responders.
(5) An estimate of the total number of
respondents and the amount of time
estimated for an average respondent to

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respond: New Account Request Data
Form (DHS Form 10015)—75,000
respondents annually/30 minutes per
respondent, New Capability Gap Data
Form (DHS Form 10011)—500
respondents annually/2 hours per
respondent, and Feedback Data Form
(DHS Form 10012)—500 respondents
annually/30 minutes per respondent.
(6) An estimate of the total public
burden (in hours) associated with the
collection: 38,750 burden hours.
Dated: April 19, 2007.
Kenneth D. Rogers,
Chief Information Officer.
[FR Doc. E7–10382 Filed 5–29–07; 8:45 am]
BILLING CODE 4410–10–P

DEPARTMENT OF HOMELAND
SECURITY
Bureau of Immigration and Customs
Enforcement
Agency Information Collection
Activities: Extension of an Existing
Information Collection; Comment
Request
30-day notice of information
collection under review; Form G–146,
Nonimmigrant checkout letter; OMB
Control No. 1653–0020.

ACTION:

The Department of Homeland
Security, U.S. Immigration and Customs
Enforcement (USICE), has submitted the
following information collection request
for review and clearance in accordance
with the Paperwork Reduction Act of
1995. The information collection was
previously published in the Federal
Register on March 30, 2007, Vol. 72, No.
61, 15143–4, allowing for a 60-day
public comment period. No comments
were received on this information
collection.
The purpose of this notice is to allow
an additional 30 days for public
comments. Comments are encouraged
and will be accepted for thirty days
until June 29, 2007.
Written comments and suggestions
regarding items contained in this notice,
and especially with regard to the
estimated public burden and associated
response time should be directed to the
Department of Homeland Security
(DHS), Ricardo Lemus, Chief, Records
Management Branch, Bureau of
Immigration and Customs Enforcement,
425 I Street, NW., Room 1122,
Washington, DC 20536; (202) 514–3211.
Written comments and suggestions
from the public and affected agencies
concerning the proposed collection of
information should address one or more
of the following four points:

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(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility;
(2) Evaluate the accuracy of the
agencies estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and
(4) Minimize the burden of the
collection of information on those who
are to respond, including through the
use of appropriate automated,
electronic, mechanical, or other
technological collection techniques or
other forms of information technology,
e.g., permitting electronic submission of
responses.
Overview of this information
collection:
(1) Type of Information Collection:
Extension of currently approved
information collection.
(2) Title of the Form/Collection: Order
to Show Cause.
(3) Agency form number, if any, and
the applicable component of the
Department of Homeland Security
sponsoring the collection: Form G–146,
Bureau of Immigration and Customs
Enforcement.
(4) Affected public who will be asked
or required to respond, as well as a brief
abstract: Primary: Individual or
Households. When an alien (other than
one who is required to depart under
safeguards) is granted the privilege of
voluntary departure without the
issuance of an Order to Show Cause, a
control card is prepared. If, after a
certain period of time, a verification of
departure is not received, actions are
taken to locate the alien or ascertain his
or her whereabouts. Form G–146 is used
to inquire of persons in the United
States or abroad regarding the
whereabouts of the alien.
(5) An estimate of the total number of
respondents and the amount of time
estimated for an average respondent to
respond: 20,000 responses at 10 minutes
(.16) per response.
(6) An estimate of the total public
burden (in hours) associated with the
collection: 3,220 annual burden hours.
Comments and/or questions; requests
for a copy of the proposed information
collection instrument, with instructions;
or inquiries for additional information
should be directed to: Ricardo Lemus,
Chief, Records Management Branch,
Bureau of Immigration and Customs
Enforcement, 425 I Street, NW., Room

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