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Form approved OMB#: 0925-0668, EXP. DATE: 02/28/2019
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the completed form to this address.

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Form approved OMB#: 0925-0668, EXP. DATE: 02/28/2019
Burden Disclosure
Public reporting burden for this collection of information is estimated to average 2 minutes per
response, including the time for reviewing instructions, searching existing data sources,
gathering and maintaining the data needed, and completing and reviewing the collection of
information. An agency may not conduct or sponsor, and a person is not required to respond to,
a collection of information unless it displays a currently valid OMB control number. Send
comments regarding this burden estimate or any other aspect of this collection of information,
including suggestions for reducing this burden, to: NIH, Project Clearance Branch, 6705
Rockledge Drive, MSC 7974, Bethesda, MD 20892-7974, ATTN: PRA# 0925-0668. Do not return
the completed form to this address.

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Essential Malaria Parasite Genes Revealed

News Releases
Media Contacts

NIAID-Funded Research Could Aid Antimalarial Drug Development

Dr. Fauci in the News

May 3, 2018

NIAID-Funded Research
News

Researchers have exploited a quirk in the genetic make-up of the
deadly malaria parasite, Plasmodium falciparum, to create
38,000 mutant strains and then determine which of the
organism's genes are essential to its growth and survival. P.
falciparum is responsible for about half of all malaria cases and
90 percent of all malaria deaths. New information about the
parasite's critical gene repertoire could help investigators
prioritize targets for future antimalarial drug development.
The international research team led by John H. Adams, Ph.D., of
the University of South Florida, was supported by the National
Institute of Allergy and Infectious Diseases (NIAID), part of the
National Institutes of Health. The study appears in the May 4
issue of Science. Rays H.Y. Jiang, Ph.D., of Universtiy of South
Florida, and Julian C. Rayner, Ph.D., of the Wellcome Trust
Sanger Institute, U.K., collaborated with Dr. Adams in this
research.

Congressional Testimony

The complete genetic sequence of P. falciparum was deter•
mined more than a decade ago, but the functions of most
of its genes remain unknown, a n d until now only a few hundred
mutant strains had been created in the lab. The difficulties in
manipulating P. falciparum stem in part from the extremely high
percentage of adenine or thymine (two of the four chemical
building blocks that make up DNA) in its genome. Standard
methods for creating mutants rely on more variation in gene
sequences and so do not work on P. falciparum. In the new
research, Dr. Adams and his colleagues created mutated
versions of nearly all the parasite's 6,000 genes with a technique
that preferentially targets areas rich in adenine and thymine,
thus exploiting the very feature that had foiled previous attempts at

Colorized scanning electron micrograph of red blood cell
infected wi th malaria paras ites, w hich are colorized in b lue.
The infected cell is in the center of the image area. To the
are uninfected cells with a smooth red surface.
Credit: NIAID

genetic manipulation.

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Form approved OMB#: 0925-0668, EXP. DATE: 02/28/2019

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Health and Human ServicesC?

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Search NIAID Q.
Search

RESEARCH

I DISEASES & CONDITIONS I

GRANTS & CONTRACTS

I CLINICAL TRIALS I NEWS & EVENTS I ABOUT NIAID
Share This:

News & Events > Newsroom > News Releases

I

Newsroom

000

Essential Malaria Parasite Genes Revealed

News Releases
Media Contacts

NIAID-Funded Research Could Aid Antimalarial Drug Development

Dr. Fauci in the News

May 3, 2018

NIAID-Funded Research
News

Researchers have exploited a quirk in the genetic make-up of the
deadly malaria parasite, Plasmodium falciparum, to create
38,000 mutant strains and then determine which of the
organism's genes are essential to its growth and survival. P.
falciparum is responsible for about half of all malaria cases and
90 percent of all malaria deaths. New information about the
parasite's critical gene repertoire could help investigators
prioritize targets for future antimalarial drug development.
The international research team led by John H. Adams, Ph.D., of
the University of South Florida, was supported by the National
Institute of Allergy and Infectious Diseases (NIAID), part of the
National Institutes of Health.The study appears in the May 4
issue of Science. Rays H.Y. Jiang, Ph.D., of Universtiy of South
Florida, and Julian C. Rayner, Ph.D., of the Wellcome Trust
Sanger Institute, U.K., collaborated with Dr. Adams in this
research.

Congressional Testimony

The complete genetic sequence of P. falciparum was deter•
mined more than a decade ago, but the functions of most
of its genes remain unknown, a n d until now only a few hundred
mutant strains had been created in the lab. The difficulties in
manipulating P. falciparum stem in part from the extremely high
percentage of adenine or thymine (two of the four chemical
building blocks that make up DNA) in its genome. Standard
methods for creating mutants rely on more variation in gene
sequences and so do not work on P. falciparum. In the new

Colorized scanning el ectron micrograph of red blood cell
infected wi th malaria paras ites, w h ich are colorized in b lue.
The infected cell is in the center of the image area. To the
are uninfected cells with a smooth red surface.
Credit: NIAID

research, Dr. Adams and his colleagues created mutated
versions of nearly all the parasite's 6,000 genes with a technique
that preferentially targets areas rich in adenine and thymine,
thus exploiting the very feature that had foiled previous attempts at genetic manipulation.

We thank you for your time taking this survey.
Your response hasbeen recorded.
Form approved OMB#: 0925-0668, EXP. DATE: 02/28/2019
Burden Disclosure
Public reporting burden for this collection of information is estimated to average 2 minutes per response, including the time for reviewing
instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of
information. An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a
currently valid OMB control number. Send comments regarding this burden estimate or any other aspect of this collection of information, including
suggestions for reducing this burden, to: NIH, Project Clearance Branch, 6705 Rockledge Drive, MSC 7974, Bethesda, MD 20892-7974, ATTN:
PRA# 0925-0668. Do not return the completed form to this address.

CONTACT US

PUBLICATIONS

HELP

ARCHIVE

Connect with NIAID
•

f '# 1n g+

...

""

r.,

,;:-::,

..

l!O

SITE MAP

INFORMAC16N EN ESPANOL

EMPLOYEE INFORMATION

Website Policies & Notices

Related Government Websites

Freedom o f Information Act(FOIA)
.
No Fear Act Data
PrivacY. PoliCY.

National Institutes o f Health 8"
Health and Human Services 8"
USA.g.QY8"